Supercritical Fluid Chromatography

Supercritical fluid chromatography (SFC) is a chromatographic technique which uses a supercritical fluid as the mobile phase.  Although SFC has been around for some time, its adaptation as an orthogonal technique to HPLC, particularly in the pharmaceutical industry, has seen an increase over the last few years.  This interest has been fuelled by the increasing requirement for high throughput and a desire for ‘greener’ techniques. Large reductions in the use of solvents have significant benefits in terms of decreased sample processing and drying-down times, as well as providing cost and safety benefits.

Hichrom supply a wide range of achiral and chiral SFC columns. Besides those listed below a number of other manufacturers offer phases which can be used under SFC conditions (e.g. Diol, Cyano and Silica phases).  Please contact us for further information on these phases.

SFC products:

• COSMOSIL achiral SFC columns - please contact Hichrom for further information
• Daicel chiral SFC columns
• ES Industries achiral SFC columns
• Kromasil achiral and chiral SFC columns
• Princeton achiral SFC columns
• Regis chiral SFC columns
• YMC achiral and chiral SFC columns  - please contact Hichrom for further information

For further technical information on the SFC technique 

For individual advice contact our Technical Support team