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Supelco is part of the Sigma-Aldrich Corporation and has been a leader in chromatography for over 30 years. From its main facility in Bellefonte, Pennsylvania, USA, Supelco researches, manufactures and supplies chromatography columns and related tools for environmental, government, food and beverage, pharmaceutical, biotechnology, medical and chemical laboratories.

 Supelco has developed several successive generations of HPLC columns, from the early SUPELCOSIL range to Discovery and the newer Ascentis. They were one of the first companies to introduce a base deactivated column, SUPELCOSIL LC-18-DB, for improved peak shapes of basic compounds. Their embedded polar group columns have evolved through several generations, including Discovery RP-AmideC16 and Ascentis RP-Amide.


Supelco specialises in four main product areas:

  • Liquid chromatography packings, columns and accessories
  • Gas chromatography packings, columns and accessories
  • Sample preparation products
  • Chemical reference standards and reagents

Key brands in the Supelco range of HPLC columns include:

Porous vinyl alcohol copolymer phases (300A pore size) for high pH applications

Newer generation of high purity silica phases

  • Ascentis Express 

Series of 2.7um and 5um phases based on Fused-Core particle technology


  • Discovery                                                                    

Series of functionalised reversed-phase HPLC columns                                                                                                                                                                                                                                             

  • Discovery BIO

Includes Wide Pore (300A) reversed-phase columns for biomolecule separations

Range includes ion exclusion columns containing sulphonated polystyrene/divinylbenzene resins in 6 different cationic forms for analysis of carbohydrates and organic acids

  • SUPELCOSIL                                                              

Range of hydrophobic, polar and ion-exchange phases 

  • Titan C18

UHPLC columns based on 1.9um porous silica particles



For further technical information on Supelco products contact our Technical Support Team