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Chiral Technologies: CHIRALPAK

CHIRALPAK immobilised phases

 

CHIRALPAK IA, IB, IC, ID, IE and IF HPLC and SFC columns are a newer generation of chiral stationary phases (CSPs), in which the polysaccharide chiral selector has been chemically immobilised on to a wide pore silica matrix. This process confers enhanced robustness and stability to these columns.

 

These innovative immobilised CSPs allow chromatographers to use essentially any organic solvent as mobile phases to develop the most challenging chiral separations. This is in contrast to traditional, coated polysaccharide phases which have restricted solvent compatibility. The broader range of solvents that can be used introduces new selectivity profiles and improved productivity compared with traditional coated polysaccharide phases.

CHIRALPAK material specifications

CHIRALPAK  phase

Chiral selector

CHIRALPAK IA

Amylose tris (3, 5-dimethylphenylcarbamate)

CHIRALPAK IB

Cellulose tris (3, 5-dimethylphenylcarbamate)

CHIRALPAK IC

Cellulose tris (3, 5-dichlorophenylcarbamate)

CHIRALPAK ID

Amylose tris (3-chlorophenylcarbamate)

CHIRALPAK IE

Amylose tris (3, 5-dichlorophenylcarbamate)

CHIRALPAK IF

Amylose tris (3-chloro, 4-methylphenylcarbamate)

 

Columns with particle sizes of 5um (CHIRALPAK IA, IB, IC, ID, IE and IF) and 3um (CHIRALPAK IA-3, IB-3, IC-3, ID-3, IE-3 and IF-3) are available. Methods can be transferred directly from 5um to 3um particle size columns for faster separations.

Immobilised phases can be used in all chromatographic modes: normal- and reversed-phase HPLC, SFC, analytical and preparative.

Column screening is simpler, faster and more successful using Daicel immobilised phases. Using the four immobilised phases IA , IB, IC and ID with alkane/alcohol solvents, these columns can separate a significant number of small molecules. Using a set of four primary screening solvents with these four phases, a separation success rate approaching 99% can be achieved.

 

 

 

 

 

 

 

 

Further technical information:

 
  • Catalogue information on CHIRALPAK immobilised phases
  • CHIRALPAK & CHIRALCEL phases for SFC  
  • CHIRALPAK anion exchange phases
  • CHIRALPAK coated phases
  • CHIRALPAK ligand exchange phases
  • CHIRALPAK protein based phases
  • CHIRALPAK zwitterionic phases 

Other Chiral Technologies products:

                   

Available literature:

  • Application guide CD
  • Instruction manual for immobilised phases in NP
  • Instruction manual for immobilised phases in RP

Or contact our Technical Support team