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Chiral Technologies: CHIRALPAK

CHIRALPAK coated phases

 

CHIRALPAK columns packed with traditional coated amylose phases are the predecessors to the newer generation of immobilised phases. They are based on a spherical high quality silica support on to which the amylose chiral selector is physically coated. This physical link can be cleaved which necessitates careful selection of solvents.

 

Columns with 3, 5 and 10um particle sizes and with analytical, semi-preparative and preparative dimensions are available. In addition, columns packed specifically for SFC applications are available.

 

The following nomenclature is used for the various series of CHIRALPAK coated phases:

Phase type series Eg
Traditional 10um phases

 e.g. AD, AS

High resolution 5um phases

– H series

 e.g. AD-H

High resolution 5um phases for reversed-phase

– RH series

e.g. AD-RH

High resolution 5um phases for SFC     

– H SFC

e.g. AD-H SFC

Ultra fast 3um phases

– 3 series

Ultra fast 3um phases for reversed-phase

– 3R series

  

In addition to the well established AD and AS phases, the newer AY and AZ chlorinated amylose based phases offer alternative separation capabilities.

 

 CHIRALPAK material specifications

PhaseChiral selectorUSP
code

AD, AD-H, AD-RH, AD-3, AD-3R, AD-H SFC

Amylose tris (3,5-dimethylphenylcarbamate)

L51

AS, AS-H, AS-RH, AS-3, AS-3R, AS-H SFC

Amylose tris ((S)-alpha-methylbenzylcarbamate)

-

AY, AY-H, AY-RH, AY-3, AY-3R, AY-H SFC

Amylose tris (5-chloro-2-methylphenylcarbamate)

-

AZ, AZ-H, AZ-RH, AZ-3, AZ-3R, AZ-H SFC

Amylose tris (3-chloro-4-methylphenylcarbamate)

-

 

Information on further CHIRALPAK phases:

  • Catalogue information on CHIRALPAK coated phases  
  • CHIRALPAK anion exchange phases  
  • CHIRALPAK immobilised phases  
  • CHIRALPAK ligand exchange phases       
  • CHIRALPAK protein based phases
  • CHIRALPAK phases for SFC      
  • CHIRALPAK zwitterionic  phases  

Other Chiral Technologies products:

Available literature:

  • Application guide CD

    

Or contact our Technical Support team